Sandra Knowles
ARTICLES BY THIS AUTHOR
- 6/24/2025
Antidepressant-induced weight gain
Antidepressants are commonly used medications, with about 16% of people in Canada using antidepressants in 2023. - 1/20/2025
Adverse drug events in outpatient settings
ADEs in the outpatient setting are common, occuring in approximately 5% of patients. Of these, 22% are considered preventable. - 1/16/2025
Antihypertensives and eczematous dermatitis
Rates of eczematous dermatitis have been increasing among older adults. - 9/26/2024
Pseudoephedrine: risk of PRES/RCVS
The European Pharmacovigilance Risk Assessment Committee reviewed reported cases and post-marketing safety data to evaluate the risks of PRES and RCVS with pseudoephedrine-containing medicines. - 9/23/2024
Do PPIs increase risk for migraine?
Proton pump inhibitors are commonly used medications for the treatment and prevention of gastric acid-related upper gastrointestinal disease. - 6/11/2024
Safety of combining PDE5 inhibitors and nitrates
Some studies have demonstrated lower mortality with phosphodiesterase-5 inhibitor treatment for erectile dysfunction in men with stable coronary artery disease, compared with no treatment. - 6/9/2024
GLP-1 agonists and suicidality
Cases of suicidality have been reported among patients using GLP-1 receptor agonists for diabetes and/or obesity. - 10/17/2023
Hormone replacement therapy and risk of dementia
Some early studies suggested that HRT may have a protective effect on the development of Alzheimer’s disease. In contrast, other research found HRT was associated with a two-fold increased risk of dementia in women aged 65 years or older. - 10/17/2023
Benzodiazepine-related toxicity: Ontario study
In Canada, the prevalence of benzodiazepine use is estimated between 5% and 10%. - 7/23/2023
Metabolic adverse effects of antipsychotics
A recent network meta-analysis investigated the mid- to long-term metabolic effects of antipsychotics in randomized controlled trials of 13 weeks’ duration or longer in patients with schizophrenia.
